Candidate gene prioritization with Endeavour
نویسندگان
چکیده
منابع مشابه
Candidate gene prioritization with Endeavour
Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a small fraction are truly relevant to the disease, phenotype or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and integrating this heterogeneous information into a global ...
متن کاملEndeavour update: a web resource for gene prioritization in multiple species
Endeavour (http://www.esat.kuleuven.be/endeavourweb; this web site is free and open to all users and there is no login requirement) is a web resource for the prioritization of candidate genes. Using a training set of genes known to be involved in a biological process of interest, our approach consists of (i) inferring several models (based on various genomic data sources), (ii) applying each mo...
متن کاملCandidate Gene Prioritization Using Network Based Probabilistic Models
We present a new gene prioritization method that learns a probabilistic knowledge model from a knowledge base and free text research documents and exploits it to prioritize candidate genes. The knowledge model is represented by a network of associations among the domain entities (e.g., genes) and is extracted from a domain knowledge base (e.g., protein-protein interaction database) or a corpus ...
متن کاملToppGene Suite for gene list enrichment analysis and candidate gene prioritization
ToppGene Suite (http://toppgene.cchmc.org; this web site is free and open to all users and does not require a login to access) is a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome. Functional annotatio...
متن کاملCandidate gene prioritization based on spatially mapped gene expression: an application to XLMR
MOTIVATION The identification of genes involved in specific phenotypes, such as human hereditary diseases, often requires the time-consuming and expensive examination of a large number of positional candidates selected by genome-wide techniques such as linkage analysis and association studies. Even considering the positive impact of next-generation sequencing technologies, the prioritization of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2016
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkw365